I have pretty limited experience as I get something that works and stick with it.
I had a WTB Trailblazer 2.8 on my 27.5+, and last fall cut it up pretty bad on the Back 40 down in Arkansas, which has notoriously sharp rocks. So that night I bought a High Roller II in Bentonville and wow, it is durable and I love how it climbs in rocky tech stuff. I have cut the sidewall once(last March at Leatherwood) and patched it, no problems otherwise and I've put ~500 miles on it. I still have the stock WTB bridger on front, which I do like as it is a 3" with a big round profile and pretty large knobs, though it looks more like a tight grid pattern compared to the HR2. It is holding up, but I am thinking about the DHF to replace it at some point. In the past i used to go more fast track on my old 26" HT 2.2", but since I got this bike, I'm liking the more aggressive tires and taking tech stuff faster than I ever dreamed of(as i moved up to a bigger wheel, tire, fork, etc... from my old 26er).
Prior to getting the 27.5+ bike, I also got new wheels for my rigid SS 29er a year ago and went with 2.4 Ardent's(which barely fit) and do like them. In fact, going from those to the 2" tires it previously had lead me to want to move to a plus size bike. Then my old 26er broke and finally pulled the trigger last fall. Anyway, I find Ardents pretty fast rolling and durable, but they don't hook up on rocks as well as the High Roller II on my 27.5+. I run them at 18psi, on Stans Arch EX rims, and have no issues. They make that rigid SS a more fun ride by far. The old 2" tires were on non-tubeless rims setup tubelss, so I kept them at 25psi min, which was a rough ride.